![]() The S-isomer has greater activity than the R-isomer. Methamphetamine has higher potency than amphetamine, but in uncontrolled situations the effects are almost indistinguishable. It increases the activity of the noradrenergic and dopamine neurotransmitter systems. Later, users may feel irritable, restless, anxious, depressed and lethargic. Following oral use, the effects usually start within 30 minutes and last for many hours. It suppresses appetite and fatigue and leads to insomnia. ![]() Methamphetamine is a CNS stimulant that causes hypertension and tachycardia with feelings of increased confidence, sociability and energy. ![]() Tablets containing methamphetamine may carry logos similar to those seen on MDMA and other ecstasy tablets. Illicit products mostly consist of powders, but the pure crystalline hydrochloride is known as 'ice'. The most common salt is the hydrochloride ( CAS-51-57-0), which occurs as a white or off-white powder or as crystals soluble in water. Methamphetamine base is a colourless volatile oil insoluble in water. ![]()
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